(1. Graduate school, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China)

This work was supported by the National Natural Science Foundation of China (82205294), the Special Sub-Project on Modernization Research of Traditional Chinese Medicine of National Key Research and Development Program of China (2019YFC1709305), the Fundamental Research Funds for the Central Public Welfare Research Institutes (XTCX2021002) and the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (CI2021A00601).