Research progress in role of abnormal metabolism of branched-chain amino acid in occurrence and development of heart failure

doi:10.11915/j.issn.1671-5403.2022.07.117

Home > Archive>Volume 21, Issue 7, 2022 >544-547. DOI:10.11915/j.issn.1671-5403.2022.07.117

Research progress in role of abnormal metabolism of branched-chain amino acid in occurrence and development of heart failure
DOI:
                        10.11915/j.issn.1671-5403.2022.07.117
                    
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Author:
                        ZHAO Fei1ZHAO Fei
First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
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NIU Xiao-Wei2NIU Xiao-Wei
Department of Cardiology, First Hospital of Lanzhou University, Lanzhou 730000, China
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LIU Yong-Ming3LIU Yong-Ming
Department of Geriatric Cardiology, First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Geriatric Medicine, Lanzhou 730000, China
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Affiliation:(1. First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;2. Department of Cardiology, First Hospital of Lanzhou University, Lanzhou 730000, China;3. Department of Geriatric Cardiology, First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Geriatric Medicine, Lanzhou 730000, China)
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Fund Project:This work was supported by the National Natural Science Foundation of China (82000277, 82060807), the Scientific Research Project ofHealth Industry of Gansu Province (GSWSKY2019-08), the Science and Technology Program of Gansu Province (21JR1RA100), theFundamental Research Funds for the China Central Universities (lzujbky-2021-kb34), and the Foundation for Scientific Research of theFirst Hospital of Lanzhou University (ldyyyn2019-46).

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Abstract:

The changes of myocardial energy metabolism play an important role in the occurrence and development of heart failure. In recent years, it has been found that the increase of plasma branched-chain amino acid (BCAAs) and its metabolites is an important feature of heart failure, and forms a malignant feedback loop, which will eventually lead to the progression of heart failure. By promoting the catabolism of BCAAs, reducing the accumulation of metabolites and restoring the metabolic balance of BCAAs are expected to become a new target for the treatment of heart failure. This article reviews the association between abnormal metabolism of BCAAs and heart failure.

Key words:amino acids, branched-chain; heart failure; metabolic remodeling

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Received:May 19,2021
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Online: July 31,2022
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