Cardiovascular disease (CVD) is the main cause of death in women, and is more common in those after menopause. Over the past two decades, the effect of menopausal hormone treatment (MHT) on cardiovascular health remains controversial. Recent studies showed that the use of MHT in younger women or in early postmenopausal women had a beneficial effect on the cardiovascular system. Hence, intervention in the critical period is crucial in the reduction of the risk for CVD in post-menopausal women. This article reviews the research progress of MHT in postmenopausal women.