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Home > Archive>Volume 20, Issue 2, 2021 >81-85. DOI:10.11915/j.issn.1671-5403.2021.02.018
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Clinical characteristics and influencing factors of nocturnal hypertension in patients with Parkinson′s disease
Author:
Affiliation:

(1. Department of Internal Medicine, Beijng 100070, China;2. Neurology Center, Beijing Tiantan Hospital, Capital Medical University, Beijng 100070, China;3. National Clinical Research Center for Neurological Diseases, Beijing 100070, China;4. Center of Parkinson′s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China;5. Beijing Key Laboratory of Parkinson′s Disease, Beijing 100053, China)

Fund Project:

This work was supported by the National Key Research and Development Program of China (2016YFC1306000, 2016YFC1306300), the National Key Research and Development Program of China-European Commission Horizon 2020 (2017YFE0118800-779238), the National Natural Science Foundation of China (81970992, 81571229, 81071015, 30770745), the Key Technology Research and Development Program of Beijing Municipal Education Commission (KZ201610025030), the Key Project of Natural Science Foundation of Beijing (4161004), the Natural Science Foundation of Beijing (7082032), Project of Scientific and Technological Development of Traditional Chinese Medicine in Beijing (JJ2018-48), and Capital Clinical Characteristic Application Research Program (Z121107001012161).

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    Abstract:

    Objective To explore the characteristics and influencing factors in patients with Parkinson′s disease (PD) complicated with nocturnal hypertension (NH). Methods From January 2017 to January 2020, a total of 150 PD patients admitted to Beijing Tiantan Hospital were consecutively recruited. The patients received 24-hour ambulatory blood pressure (BP) monitoring and were divided into PD with NH (PD-NH) group and PD with no NH (PD-nNH) group. The patient′s demographic data was recorded, and the scales for outcomes in Parkinson′s disease-autonomic (SCOPA-AUT) was used to evaluate the patient′s autonomic symptoms. The standard deviations of systolic BP and diastolic BP in the daytime, at night and during the whole day were collected. Echocardiography was performed, and data were recorded of the left atrium diameter, the left ventricular end-diastolic diameter, the left ventricular posterior wall thickness, end-diastolic interventricular septal thickness and left ventricular ejection fraction. SPSS statistics 21.0 was used for data analysis. Results Among 150 PD patients, 96 were complicated with NH. Compared with the PD-nNH group, more patients had hypertension and higher SCOPA-AUT score in the PD-NH group (P<0.05). The standard deviations of all-day systolic BP, night-time systolic BP and night-time diastolic BP in the PD-NH group were significantly higher than those in the PD-nNH group (P<0.05). The end-diastolic interventricular septal thickness and the left ventricular posterior wall thickness in PD-NH group were significantly greater than those in PD-nNH group (P<0.05). Logistic regression analysis showed that the standard deviation of night-time systolic BP (OR=1.160,95%CI 1.010-1.332, P=0.035) and the end-diastolic interventricular septal thickness (OR=1.589,95%CI 1.059-2.384, P=0.025) were independent influencing factors of PD-NH. Conclusion The incidence of NH is high in PD patients. The increased standard deviation of systolic BP at night and the increase of end-diastolic interventricular septal thickness are independent influencing factors of PD-NH.

    Reference
    [1] Pont-Sunyer C, Hotter A, Gaig C, et al.The onset of nonmotor symptoms in Parkinson′s disease (the ONSET PD study) [J].Mov Disord,2015,30(2):229-237.DOI:10.1002/mds.26077.
    [2] Kim JS, Lee SH, Oh YS, et al.Arterial stiffness and cardiovascular autonomic dysfunction in patients with Parkinson′s disease[J].Neurodegener Dis,2017,17(2-3):89-96.DOI:10.1159/000450613.
    [3] Postuma RB, Berg D, Stern M, et al.MDS clinical diagnostic criteria for Parkinson′s disease[J].Mov Disord,2015,30(12):1591-1601.DOI:10.1002/mds.26424.
    [4] Cho MC.Clinical significance and therapeutic implication of nocturnal hypertension:relationship between nighttime blood pressure and quality of sleep[J].Korean Circ J,2019,49(9):818-828.DOI:10.4070/kcj.2019.0245.
    [5] Tomlinson CL, Stowe R, Patel S, et al.Systematic review of levodopa dose equivalency reporting in Parkinson′s disease[J].Mov Disord,2010,25(15):2649-2653.DOI:10.1002/mds.23429.
    [6] Nakanishi K, Jin Z, Homma S, et al.Night-time systolic blood pressure and subclinical cerebrovascular disease:the cardiovascular abnormalities and brain lesions (CABL) study[J].Eur Heart J Cardiovasc Imaging,2019,20(7):765-771.DOI:10.1093/ehjci/jey221.
    [7] Kulshreshtha D,Ganguly J,Jog M.Managing autonomic dysfunction in Parkinson′s disease:a review of emerging drugs[J].Expert Opin Emerg Drugs,2020,25(1):37-47.DOI:10.1080/14728214.2020.1729120.
    [8] Sharabi Y, Goldstein DS.Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease[J].J Neurol Sci,2011,310(1-2):123-128.DOI:10.1016/j.jns.2011.06.047.
    [9] Maruhashi T, Kihara Y, Higashi Y.Perspectives on the management of hypertension in Japan[J].Expert Opin Pharmacother,2020,21(10):1179-1187.DOI:10.1080/14656566.2020.1724958.
    [10] Jost WH.An update on the recognition and treatment of autonomic symptoms in Parkinson′s disease[J].Expert Rev Neurother,2017,17(8):791-799.DOI:10.1080/14737175.2017.1345307.
    [11] Müller B, Larsen JP, Wentzel-Larsen T,et al.Autonomic and sensory symptoms and signs in incident, untreated Parkinson′s disease:frequent but mild[J].Mov Disord,2011,26(1):65-72.DOI:10.1002/mds.23387.
    [12] Vishram JK, Dahlöf B, Devereux RB, et al.Blood pressure variability predicts cardiovascular events independently of traditional cardiovascular risk factors and target organ damage:a LIFE substudy[J].J Hypertens, 2015,33(12):2422-2430.DOI:10.1097/HJH.0000000000000739.
    [13] Lin L, Zhang H, Yang J, et al.Nocturnal and circadian rhythm of blood pressure is associated with renal structure damage and function in patients with IgAN[J].Arch Med Res,2016,47(1):25-32.DOI:10.1016/j.arcmed.2016.01.001.
    [14] Oh J, Lee CJ, Kim IC, et al.Association of morning hypertension subtype with vascular target organ damage and central hemodyna mics[J].J Am Heart Assoc,2017,6(2):e005424.DOI:10.1161/JAHA.116.005424.
    [15] Abdalla M, Caughey MC, Tanner RM, et al.Associations of blood pressure dipping patterns with left ventricular mass and left ventri-cular hypertrophy in blacks:the Jackson Heart Study[J].J Am Heart Assoc,2017,6(4):e004847.DOI:10.1161/JAHA.116.004847.
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  • Received:May 10,2020
  • Online: March 01,2021
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