Sarco-osteopenia is a common comorbidity cluster in the elderly population, resulting from aging, diseases, behaviors, nutrition, genetics and other factors, which seriously affects their health and quality of life. Therefore, screening and evaluation of the two diseases is of great importance, and early identification and intervention constitute the key to the improved prognosis. In terms of prevention and treatment, exercises, nutrition and drug therapy were mainly adopted as comprehensive intervention for the bones and muscles. This article reviews the comorbidity cluster in the respects of its incidence, adverse outcomes, risk factors, screening, evaluation and intervention.