Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world with insidious early symptoms and poor prognosis. In clinical practice, there are some limitations in its early diagnosis. A wide array of studies have shown that micro ribonucleic acid-375 (miR-375) is closely related to the occurrence and development of HCC, exerting an effect by targeting oncogenic signaling pathways, thus serving as a marker of early diagnosis or prognosis of HCC. This article reviews the recent progress in the research on miRNA-375 and HCC, with a view of providing a theoretical basis for the early diagnosis, treatment and prognosis of HCC.