Objective To investigate the relationship between the platelet-to-lymphocyte ratio (PLR) and prognosis of the patients who underwent thrombectomy for acute anterior circulation ischemic stroke. Methods A retrospective analysis was made of demographic data of 92 patients having undergone thrombectomy for acute anterior circulation ischemic stroke. On the basis of a PLR level cut-off value of 168 from receiver operating characteristic (ROC) curve, the patients were divided into two groups:PLR＞168 group (n=48) and PLR≤168 group (n=44). The two groups were compared in clinical indices including success rate of postoperative revascularization and modified Rankin scale (mRS) scores at postoperative 30 and 90 days. Data was processed using SPSS statistics 19.0. ROC curve was used to assess the correlation between PLR and prognosis. Results Successful revascularization were 70.8% in the PLR＞168 group against 90.9% in the PLR≤168 group (P=0.011). At postoperative 30 days, patients with mRS≤2 were significantly more in the PLR≤168 group (54.5%) than in the PLR> 168 group (18.8%, P=0.001). Compared with the PLR＞168 group at postoperative 90 days, the PLR≤168 group had significantly more patients with mRS≤2 (56.5% vs 22.9%, P=0.001) and significantly lower mortality rate (27.1% vs 9.1%, P=0.026). The PLR value predicted a cut-off point of 168 with a sensitivity of 68%, a specificity of 67%, and the area under the ROC curve of 0.738 for the prognosis of patients having undergone pre-circumferential mechanical thrombectomy for acute cerebral infarction complicated with large vascular occlusion. Conclusion High PLR is associated with the poor prognosis of the patients having undergone mechanical thrombectomy for with cerebral infarction caused by anterior circulation cerebral vascular occlusion.