Objective To investigate the prognostic value of preoperative fibrinogen (FIB) combined with postoperative carcino-embryonic antigen (CEA) in the patients with stage Ⅱ colon cancer in view of providing reference for clinical diagnosis and treatment. Methods A total of 129 patients with stage Ⅱ colon cancer were enrolled in this study, who were treated in the Department of Gastroenterology of Dali Bai Autonomous Prefecture People′s Hospital from March 2010 to March 2013. They were followed up for 5 years and were divided into good prognosis group and poor prognosis group, depending on whether the patient had an endpoint. SPSS statistics 19.0 was used for statistical analysis and Kaplan-Meier for survival analysis on all patients with survival curves being plotted. Cox regression analysis was performed for the factors that may affect survival time. Results The Kaplan-Meier survival curves showed a poor prognosis rate of 26.27%(31/118), and the number of patients with poor prognosis increased with time and more obviously at month 48. Multivariate Cox regression analysis predicted adenocarcinoma (RR=2.79,5%CI 1.889-4.121; P=0.028), mucinous carcinoma (RR=2.81, 95%CI 1.948-4.054; P=0.041), undifferentiated cancer (RR=2.83,5%CI 2.016-3.972; P=0.029), left colon cancer (RR=2.72,5%CI 1.476-5.014; P=0.024), right colon cancer (RR=2.71,5%CI 1.514-4.850; P=0.035), increased preoperative FIB (RR=2.49,5%CI 1.499-4.137; P=0.033), and increased postoperative CEA (RR=2.62,5%CI 1.659-4.137; P=0.026) all affected the prognosis. The preoperative FIB had an area under the receiver operating characteristic curve (AUC) of 0.581(95%CI 0.459-0.694), with an optimal cut-off point of 7.27, a sensitivity of 68.8% and a specificity of 65.4%. The AUC for postoperative CEA measured 0.773 [95%CI (0.712-0.893)] with an optimal cut-off point of 5.78, a sensitivity of 61.3% and a specificity of 78.9%. The preoperative FIB combined with postoperative CEA had an AUC of 0.812, with a sensitivity of 74.1% and a specificity of 83.2%. Conclusion Preoperative FIB and postoperative CEA are risk factors for the prognosis in the patients with stage Ⅱ colon cancer, and their combination can enhance the sensitivity and specificity of the prediction, suggesting potential clinical value.