Sick sinus syndrome (SSS) is a group of clinical syndromes caused by lesions in sinoatrial node and its surrounding tissues. Its occurrence may be due to that a variety of reasons affect sinoatrial node cells and their surrounding tissues and thus lead to pacing and conduction dysfunction, which is mainly manifested as slow arrhythmia. In addition to the clinical treatment of electronic pacemakers, there are few studies on drug therapy. Studies show that ginsenosides and calcium dibutyryladenosine cyclophosphate can regulate myocardial cell metabolism and improve the function of the sinus node, and are effective drugs for SSS treatment. In this article, we reviewed the pathogenesis, etiology and drug treatment of SSS, so as to provide reference for clinical guidance of drug use.