Objective To investigate the effects of Aescuven forte on microcirculation for the treatment of chronic venous insufficiency (CVI). Methods A total of 40 outpatients were enrolled in this study from Vascular Surgery Department of Peking Union Hospital and Chifeng Municipal Hospital from March 2016 to August 2017. They were divided into Aescuven forte group (n=23) and control group (n=17). In a course of 4 weeks, the former were treated with Aescuven forte and pressure (elastic stockings), while the latter only with pressure. Observation focused on the primary efficacy indicators [Venous Insufficiency Epidemiological and Economic Studies-quality of life/symptom score (VEINES-QOL/Sym), transcutaneous oxygen pressure (TcPO₂) and skin temperature],secondary efficacy indicators [temperature-controlled blood blow and post-occlusion reactive hyperaemia (PORH)] and adverse reactions, and efficacy and safety were evaluated. SPSS statistics 20.0 was used to perform the statistical analysis. Student＇s t test, Mann-Whitney U test or Chi-square test was employed for comparison between two groups. Results Totally 36 patients (22 in the Aescuven forte group and 14 in the control group) finished the course of the treatment. The readings before vs. after treatment in the Aescuven forte group were VEINES-QOL [(69.3±13.5) vs(76.7±11.9) scores], VEINES-Sym [(31.9±7.9)vs(36.0±7.4)scores], TcPO₂[(45.2±22.3) vs(56.3±16.5)mmHg], skin temperature [32.6(31.5,33.9)℃ vs 31.8(31.0,2.9)℃] and the temperature-controlled blood flow [(151.4±123.0)% vs(418.0±179.5)%], and the differences were statistically significant (P<0.05). The readings before vs. after treatment in the control group were VEINES-QOL [(64.0±16.1) vs(69.0±16.7)scores], VEINES-Sym [(29.3±7.7) vs(32.6±7.9)scores], and TcPO₂ [(39.6±16.8) vs(51.4±9.9)mmHg], and the differences were statistically significant (P<0.05). Significant difference was observed in temperature-controlled blood flow between two groups[(266.6±170.1)% vs(-110.1±160.5)%, P<0.05]. Conclusion Our findings indicated that Aescuven forte may improve the quality of life and relieve the symptoms of the patients with CVI, and that a correlation could be established between curative effects and the improved microcirculation. Parameters such as TcPO₂, skin temperature, temperature-controlled blood flow may indicate the changes of microcirculation, implying a relation between the pathogenesis of CVI and the alteration of microcirculation.