According to the data from the sixth nationwide population census, 178 million people in China (13%) were over 60 years old in 2010. Aging is an independent risk factor for many chronic diseases. Epidemiological studies show that more than 50% of the elderly have 3 or more chronic diseases with distinct characteristics. The concept of geriatric multimorbidity indicates that the clinical focus of geriatrics has shifted from the traditional model of subspecialties to the integrative medicine which include comprehensive evaluation and treatment. In 2012, the American Geriatrics Society (ACS) provided the stepwise patient-centered care approach for diagnosis and treatment of older adults with multiple chronic conditions. This review aimed to describe the basement, development, comprehensive evaluation, and management system of geriatric multimorbidity.