Objective To observe the safety and effectiveness of different doses of atorvastatin calcium for patients with unstable angina pectoris (UA) and non-revascularization. Methods Thirty-eight elderly patients with UA and non-revascularization were randomly divided into 2 groups. One group received atorvastatin calcium 20mg daily, the other group 40mg instead. Total cholesterol(TC), triglyceride (TG), low-density lipoprotein cholesterol(LDL-C) and lipid profiles were measured at 1 and 3 months, as well as Holter examination results, main adverse cardiac events（MACE） and adverse drug reaction. Results After treatment, TC, TG and LDL-C in two groups were significantly reduced (P＜0.05). Compared with 20mg group, both the degree and the duration of ischemic ST segment depression were significantly decreased (P＜0.05), and the incidence of MACE, including nonfatal myocardial infarction, recurrent angina pectoris and rehospitalization due to symptomatic myocardial ischemia, was significantly lower in 40mg group (P＜0.05). There was no significant difference in the incidence of adverse drug reaction between the two groups (P＞0.05). Conclusion For elderly patients with UA and non-revascularization, atorvastatin calcium both the dose 20mg/d and 40mg/d can regulate effectively the blood lipid profiles. Atorvastatin calcium at the dose of 40mg/d has more significant effectiveness.