Objective To investigate the levels of von Willebrand factor(vWF),type 1 plasminogen activator inhibitor(PAI-1) and adiponectin in coronary heart disease patients with hyperglycemia.Methods Oral glucose tolerance test was carried out in the patients with coronary heart disease and different abnormal glucose metabolism,including diabetes mellitus(DM,n=44,26.99%),impaired glucose tolerance(IGT,n=59,24.38%),impaired fasting glucose(n=15,7.46%);and 40 patients(24.54%)with normal glucose tolerance(NGT) as the control group.The level of vWF,PAI-1 and adiponectin was measured by ELISA for all these patients.Results vWF level increased in DM and IGT groups compared with NGT group,and showed significant statistical signiticance;PAI-1 level increased in DM group with statistical significance;adiponectin level of IGT and DM groups was higher than that of NGT group,and showed significant statistical signiticance.Conclusion Hyperglycemia causes high vWF and PAI-1 level,low adiponectin level,and leads to severe endothelial lesion.It is essential to discover and control hyperglycemia as early as possible to prevent the onset and development of coronary heart disease.