Obstructive sleep apnea-hypopnea syndrome (OSAHS) is closely associated with hypertension. Studies claim OSAHS as the most common cause of secondary hypertension and an important cause of refractory hypertension. The mechanism of hypertension caused by OSAHS is complex, and multiple mechanisms are involved in the occurrence of hypertension, among which the enhancement of sympathetic nerve activity and intermittent hypoxia (IH)in patients with OSAHS may be an important cause. The diagnosis of OSAHS-associated hypertension depends on polysomnography and blood pressure. Continuous positive airway pressure (CPAP) is the preferred treatment for OSAHS patients. In OSAHS patients with hypertension, aldosterone antagonists, mandibular advancement devices (MAD) and inspiratory muscle training (IMT) should be considered in clinical practice.