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创刊人 王士雯
主 编 范利
执行主编 陈韵岱
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
李娇娇,陈雅,张慧,黎梦丽,王丽.苏州市某社区老年肌少症人群血脂状况及其与肌少症发生的相关性[J].中华老年多器官疾病杂志,2023,22(1):6~11
苏州市某社区老年肌少症人群血脂状况及其与肌少症发生的相关性
Association between blood lipid profile and sarcopenia in elderly people in one community in Suzhou
投稿时间:2022-07-27  
DOI:10.11915/j.issn.1671-5403.2023.01.002
中文关键词:  老年人  血脂  肌少症  骨骼肌质量
英文关键词:aged  blood lipid profile  sarcopenia  skeletal muscle mass This work was supported by Research Project in Humanities and Social Sciences of Soochow University
基金项目:苏州大学人文社会科学科研项目(21XM2012);国家自然科学基金青年项目(81501944)
作者单位E-mail
李娇娇 苏州大学苏州医学院护理学院,江苏 苏州215006 li-wang-1@suda.edu.cnassociation 
陈雅 苏州大学苏州医学院护理学院,江苏 苏州215006 li-wang-1@suda.edu.cnassociation 
张慧 苏州大学苏州医学院护理学院,江苏 苏州215006
苏州卫生职业技术学院,江苏 苏州 215009 
li-wang-1@suda.edu.cnassociation 
黎梦丽 苏州大学苏州医学院护理学院,江苏 苏州215006
香港理工大学护理学院,香港999077 
li-wang-1@suda.edu.cnassociation 
王丽 苏州大学苏州医学院护理学院,江苏 苏州215006 li-wang-1@suda.edu.cnassociation 
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中文摘要:
      目的 探讨血脂水平与肌少症诊断指标及肌少症发生的相关性。方法 采用方便抽样,收集1534例苏州市社区老年人的一般资料、血脂水平及身体成分,进行握力及6米步速测试,依据亚洲肌少症工作组2019年诊断标准,分为肌少症人群与非肌少症人群,比较两类人群血脂状况差异,探讨血脂与肌少症相关性。采用SPSS 23.0软件进行数据分析。根据数据类型,组间比较分别采用t检验、Mann-Whitney U检验,χ2检验以及相关和回归分析。结果 与非肌少症人群相比,肌少症人群的极低密度脂蛋白胆固醇[(0.49±0.18)和(0.53±0.29)mmol/L]、甘油三酯[TG,(1.57±0.92)和(1.76±1.22)mmol/L]、甘油三酯/高密度脂蛋白胆固醇比值[TG/HDL-C,(1.26±1.10)和(1.52±1.39)]显著较低(均P<0.05);而HDL-C[(1.45±0.37)和(1.31±0.32)mmol/L; P<0.01]、总胆固醇[TC,(5.17±1.03)和(4.97±0.96)mmol/L; P<0.05]显著更高;高TG发生率[29.10%(55/189)和36.28%(488/1345);P<0.05]较低;高TC发生率[48.15%(91/189)和36.88%(496/1345);P<0.01]更高。同时,四肢骨骼肌质量指数(ASMI)与HDL-C及TC水平呈负相关(r=-0.289、-0.202,P<0.001)。Logistic回归分析显示,年龄更大(OR=1.121,95%CI 1.091~1.152)、HDL-C更高(OR=2.133,95%CI 1.206~3.773)是肌少症发生的危险因素(P<0.01),性别为男性(OR=0.539,95%CI 0.372~0.781)、合并其他慢性病(OR=0.599,95%CI 0.413~0.868)是肌少症发生的保护因素(P<0.01)。结论 HDL-C升高与骨骼肌质量下降相关,是肌少症发生的危险因素。社区体检中对于HDL-C水平较高老年人更应关注其肌肉质量和功能变化,必要时进行肌量下降和肌少症筛查。
英文摘要:
      Objective To explore the correlation of blood lipid profile with the diagnostic indicators of sarcopenia and its occurrence. Methods A total of 1 534 elderly people in a community in Suzhou were recruited using convenience sampling method, and their general information, blood lipid levels, and body composition were collected. Handgrip strength and six-meter usual gait speed were measured. According to the Asian Sarcopenia Working Group 2019 Consensus Update on Sarcopenia Diagnosis, they were divided into sarcopenia group and non-sarcopenia group. The two groups were compared in blood lipid profile to explore its correlation with sarcopenia. SPSS statistics 23.0 was used for statistical analysis. Data comparison between two groups was perfomed using t test, Mann-Whitney U test or χ2 test depending on data type. Crrelation and regression analysis were also performed. Results The very low-density lipoprotein cholesterol [(0.49±0.18) vs (0.53±0.29) mmol/L], triglyceride (TG) [(1.57±0.92) vs (1.76±1.22) mmol/L], and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) [(1.26±1.10) vs (1.52±1.39)] were significantly lower in the sarcopenic population than the non-sarcopenic population (P<0.05). The HDL-C [(1.45±0.37) vs (1.31±0.32) mmol/L; P<0.01] and total cholesterol (TC) [(5.17±1.03) vs (4.97±0.96) mmol/L;P<0.05] were significantly higher in the sarcopenic population than the non-sarcopenic population. Compared with non-sarcopenic population, the incidence of high TG [29.10% (55/189) vs 36.28% (488/1 345); P<0.05] in sarcopenic population was lower, and that of high TC [48.15% (91/189) vs 36.88% (496/1 345); P<0.01] was significantly higher. At the same time, the appendicular skeletal muscle mass index was negatively correlated with the level of HDL-C and TC (r=-0.289, -0.202; P<0.001). Logistic regression analysis showed that advanced age (OR=1.121,95%CI 1.091-1.152) and high HDL-C level (OR=2.133,95%CI 1.206-3.773) were risk factors for sarcopenia (P<0.01), and that male gender(OR=0.539,95%CI 0.372-0.781) and comorbidity with other chronic diseases (OR=0.599, 95%CI 0.413-0.868) were protective factors for sarcopenia (P<0.01). Conclusion Elevated HDL-C is associated with decreased skeletal muscle mass and is a risk factor for sarcopenia. In physical examination in a community, more attention should be paid to the elderly people with high HDL-C levels in changes of muscle mass and function, and they should be screened for pre-sarcopenia and sarcopenia if necessary.
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