| 姚赫,林雅军.支链氨基酸对寿命调控作用的研究进展[J].中华老年多器官疾病杂志,2022,21(10):793~796 |
| 支链氨基酸对寿命调控作用的研究进展 |
| Research progress in lifespan regulation by branched-chain amino acids |
| 投稿时间：2022-06-08 |
| DOI：10.11915/j.issn.1671-5403.2022.10.170 |
| 中文关键词: 氨基酸,支链 寿命 调控作用 衰老 |
| 英文关键词:amino acids, branched-chain lifespan regulatory effect aging This work was supported by National Natural Science Foundation of China |
| 基金项目:国家自然科学基金(81671391)；北京医院“科技新星”项目(BJ-2016-033) |
| 作者 | 单位 | E-mail | | 姚赫 | 北京医院国家老年医学中心,国家卫生健康委北京老年医学研究所,国家卫生健康委老年医学重点实验室,中国医学科学院老年医学研究院,北京,100730 | linyajun2000@126.comresearch | | 林雅军 | 北京医院国家老年医学中心,国家卫生健康委北京老年医学研究所,国家卫生健康委老年医学重点实验室,中国医学科学院老年医学研究院,北京,100730 | linyajun2000@126.comresearch |
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| 中文摘要: |
| 支链氨基酸对糖脂代谢、蛋白质合成和寿命等具有重要的调节作用。许多研究报道了循环支链氨基酸水平或饮食摄入支链氨基酸与寿命、骨骼肌减少症、肥胖及糖尿病等疾病息息相关。其中,在不同动物模型中支链氨基酸与寿命之间往往存在相反的作用效果。本文综述了支链氨基酸的生物学特征及其在寿命调控中两种相反的作用及机制,以期为支链氨基酸对衰老的干预研究提供崭新的思路及合理的依据。 |
| 英文摘要: |
| Branched-chain amino acids play an important role in regulating glucose and lipid metabolism, protein synthesis, and lifespan. Many studies have reported that the level of circulating branched-chain amino acids or their dietary intake is closely associated with life expectancy, sarcopenia, obesity, and diabetes mellitus. In different animal models, branched-chain amino acids and lifespan are often found to have opposite effects. This paper reviews the biological characteristics of branched-chain amino acids and their two opposite functions and mechanisms in regulating lifespan to provide new insight into and a reasonable basis for the intervention of branched-chain amino acids on aging. |
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