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解放军总医院
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解放军总医院医学创新研究部、国家老年疾病临床医学研究中心(解放军总医院)、解放军总医院第六医学中心心血管病医学部
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中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
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E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
徐宁,晋梦頔,李文,王媛,刘倩,傅镜竹,杜汋,黄国伟.膳食模式与老年人血清同型半胱氨酸水平的相关性[J].中华老年多器官疾病杂志,2022,21(10):731~734
膳食模式与老年人血清同型半胱氨酸水平的相关性
Relationship between dietary pattern and serum homocysteine level in Chinese elderly adult
投稿时间:2022-06-07  
DOI:10.11915/j.issn.1671-5403.2022.10.159
中文关键词:  老年人  膳食模式  同型半胱氨酸
英文关键词:aged  dietary pattern  homocysteine This work was supported by Key Program of National Natural Science Foundation of China
基金项目:国家自然科学基金重点项目(81730091)
作者单位E-mail
徐宁 天津医科大学公共卫生学院,天津 300070 huangguowei@tmu.edu.cnrelationship 
晋梦頔 天津医科大学公共卫生学院,天津 300070 huangguowei@tmu.edu.cnrelationship 
李文 天津医科大学公共卫生学院,天津 300070
天津市环境营养与人群健康重点实验室 天津 300070 
huangguowei@tmu.edu.cnrelationship 
王媛 天津医科大学公共卫生学院,天津 300070
天津市环境营养与人群健康重点实验室 天津 300070 
huangguowei@tmu.edu.cnrelationship 
刘倩 天津医科大学公共卫生学院,天津 300070 huangguowei@tmu.edu.cnrelationship 
傅镜竹 天津医科大学公共卫生学院,天津 300070 huangguowei@tmu.edu.cnrelationship 
杜汋 天津医科大学公共卫生学院,天津 300070
天津市环境营养与人群健康重点实验室 天津 300070 
huangguowei@tmu.edu.cnrelationship 
黄国伟 天津医科大学公共卫生学院,天津 300070
天津市环境营养与人群健康重点实验室 天津 300070 
huangguowei@tmu.edu.cnrelationship 
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中文摘要:
      目的 探讨社会人口因素、膳食模式、叶酸生化水平对老年人血清同型半胱氨酸(HCY)水平的影响。方法 选择天津市宝坻区4319例年龄≥60岁的老年人作为研究对象。血清HCY>15μmol/L判定为高同型半胱氨酸血症(HHCY)。根据血清HCY水平分为HHCY组(1477例)和正常组(2842例)。采用食物频率法收集饮食信息,主成分分析法提取膳食模式,分析不同膳食模式对血清叶酸和HCY水平的影响。采用SPSS 25.0统计软件进行数据分析。根据数据类型,分别采用t检验、单因素方差分析或者χ2检验进行组间比较。结果 与正常组相比,HHCY组年龄更大,男性更多,BMI更高,血清叶酸水平更低,差异均有统计学意义(均P<0.05)。主成分分析提取了三种膳食模式,其中蛋奶素食膳食模式有利于降低血清HCY水平,升高血清叶酸水平(均P<0.001)。动物膳食模式与血清叶酸水平降低有关(P<0.001),与血清HCY水平无显著关系。豆类膳食模式与血清HCY水平降低有关(P<0.05),与血清叶酸水平无显著关系。结论 建议天津市农村老年人在日常的膳食中适量增加蔬菜、水果、蛋类、奶制品、坚果种子、大豆及其他豆类等的摄入;同时适度限制动物性食品及油炸食品摄入,有利于降低HCY水平,保护心脑血管健康。
英文摘要:
      Objective To investigate the effects of social/population factors, dietary patterns, and folate biochemical level on serum homocysteine(HCY) level in the elderly. Methods A total of 4319 elderly people (≥60 years) in Baodi District of Tianjin were selected as the subjects. Serum HCY >15 μmol/L was defined as hyperhomocysteine (HHCY), and the elderly were divided into HHCY group (n=1 477) and non-HHCY group (n=2 842). Dietary information was collected by food frequency method, dietary patterns were extracted by principal component analysis, and the effects of different dietary patterns on serum folate and HCY levels were analyzed. SPSS 25.0 was used for statistical analysis. Student′s t-test, One-way ANOVA or Chi-square test was employed for intergroup comparison based on data types. Results Compared with the non-HHCY group, the HHCY group was older with more males, higher BMI, and lower serum folate levels (all P<0.05). Three dietary patterns were extracted in the principal component analysis, among which the ovo-lacto vegetarian dietary pattern was beneficial to a decrease in serum HCY level and an increase of serum folate level (all P<0.001). The animal pattern was associated with a decreased serum folate level (P<0.001), but not significantly with serum HCY level. Beans dietary pattern was associated with the decrease of serum HCY (P<0.05), but not significantly with serum folate level. Conclusion It is suggested that the rural elderly in Tianjin should increase the intake of vegetables, fruits, eggs, dairy products, nuts and seeds, soybeans and other legumes in their daily diet but moderately reduce the intake of animal food and fried food, which is beneficial to reduce HCY and protect the cardiovascular and cerebrovascular health.
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