在线办公
期刊论坛
主 管
解放军总医院
主 办
解放军总医院医学创新研究部、国家老年疾病临床医学研究中心(解放军总医院)、解放军总医院第六医学中心心血管病医学部
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
柏静,孙宏丽,芦秋彤,常欣.可溶性生长刺激表达基因2联合N末端B型利钠肽原对沙库巴曲缬沙坦干预老年射血分数轻度减低心力衰竭患者的预后评估价值[J].中华老年多器官疾病杂志,2022,21(9):679~683
可溶性生长刺激表达基因2联合N末端B型利钠肽原对沙库巴曲缬沙坦干预老年射血分数轻度减低心力衰竭患者的预后评估价值
Predictive value of soluble growth STimulation expressed gene 2 combined with N-terminal pro-B-type natriuretic peptide for prognosis of elderly patients with heart failure with mid-range ejection fraction after sacubitril-valsartan intervention
投稿时间:2022-02-08  
DOI:10.11915/j.issn.1671-5403.2022.09.147
中文关键词:  老年人  射血分数轻度减低心力衰竭  沙库巴曲缬沙坦  可溶性生长刺激因子2  N末端B型利钠肽原
英文关键词:aged  heart failure with mid-range ejection fraction  sacubitril-valsartan  soluble growth STimulation expressed gene 2  N-terminal pro-B-type natriuretic peptide This work was supported by the Project of Science and Technology Plan of Chengde City
基金项目:承德市科学技术课题计划项目(202109A180)
作者单位E-mail
柏静 承德市中心医院药剂科,河北 承德 067000 cdzxyyzkb@163.compredictive 
孙宏丽 承德市中心医院药剂科,河北 承德 067000 cdzxyyzkb@163.compredictive 
芦秋彤 承德市中心医院药剂科,河北 承德 067000 cdzxyyzkb@163.compredictive 
常欣 承德市中心医院药剂科,河北 承德 067000 cdzxyyzkb@163.compredictive 
摘要点击次数: 52
全文下载次数: 52
中文摘要:
      目的 探讨可溶性生长刺激表达基因2(sST2)与N末端B型利钠肽原(NT-proBNP)对沙库巴曲缬沙坦(SV)干预老年射血分数轻度减低心力衰竭(HFmrEF)患者预后的评估价值。方法 选取2018年4月至2020年4月于承德市中心医院住院治疗的81例HFmrEF患者为研究对象,均使用SV治疗。分析HFmrEF患者应用SV治疗后影响复合终点事件发生的危险因素,并评估sST2联合NT-proBNP对SV干预HFmrEF患者预后的价值。采用SPSS 26.0统计软件进行数据分析。根据数据类型,分别采用t检验、秩和检验、χ2检验或Fisher精确检验进行组间比较。应用Cox风险评估模型分析复合终点事件与变量间的关系。结果 随访6个月后,19例患者出现复合终点事件(复合终点事件组),62例患者未出现复合终点事件(非复合终点事件组)。与非复合终点事件组比较,复合终点事件组心率较快,血肌酐水平较低,sST2、NT-proBNP水平较高,左房内径较大,有吸烟史、PCI或溶栓史、急性心肌梗死史比例更高,差异均有统计学意义(P<0.05)。单变量与多变量Cox回归分析显示,sST2与NT-proBNP水平是HFmrEF患者应用SV治疗后影响复合终点事件发生的独立危险因素(P<0.05)。受试者工作特征(ROC)曲线分析显示,sST2联合NT-proBNP预测复合终点事件的诊断价值均高于单一指标。结论 sST2联合NT-proBNP对SV干预老年HFmrEF患者的预后具有较好的评估价值。
英文摘要:
      Objective To investigate the value of soluble growth STimulation expressed gene 2 (sST2) combined with N-terminal pro-B-type natriuretic peptide (NT-proBNP) to evaluate the prognosis of elderly patients with heart failure with mid-range ejection fraction (HFmrEF) after sacubitril-valsartan (SV) intervention. Methods A total of 81 HFmrEF patients admitted to our hospital from April 2018 to April 2020 were recruited in and treated with SV intervention. The risk factors affecting the occurrence of composite endpoints in HFmrEF patients with SV treatment were analyzed, and the value of sST2 combined with NT-proBNP for the prognosis of HFmrEF patients after SV intervention was evaluated. SPSS statistics 26.0 was used for data analysis. According to the data types, student′s t test, Rank sum test, Chi-square test or Fisher exact test was performed for comparison between groups. Cox hazards model was used to analyze the relationship between composite endpoints and variables. Results After 6 months of follow-up, 19 patients experienced composite endpoints and were included in the composite endpoint group, and the remaining 62 patients were included in the non-composite endpoint group. The composite endpoint group had significantly higher heart rate, lower serum creatinine, higher sST2 and NT-proBNP levels, larger left atrial diameter, and larger proportions of smoking history, PCI or thrombolysis history, and acute myocardial infarction history when compared with the non-composite endpoint group (P<0.05). Univariate and multivariate Cox regression analyses showed that sST2 and NT-proBNP levels were independent risk factors for composite endpoints in HFmrEF patients after SV treatment (P<0.05). Receiver operating characteristic (ROC) curve analysis indicated that the diagnostic value of sST2 combined with NT-proBNP was higher than that of a single index in predicting composite endpoint events. Conclusion sST2 combined with NT-proBNP has a significant predictive value for the prognosis of elderly HFmrEF patients after SV intervention.
查看全文    下载PDF阅读器
关闭