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解放军总医院
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解放军总医院医学创新研究部、国家老年疾病临床医学研究中心(解放军总医院)、解放军总医院第六医学中心心血管病医学部
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中华老年多器官疾病杂志编辑委员会
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E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
尹慧君,李晓利,徐成,田玲,李彬,胡超,王耀辉,王晓晴,邓玲,李炜.北京某地区老年人群非酒精性脂肪性肝病的临床特征及影响因素[J].中华老年多器官疾病杂志,2022,21(9):651~654
北京某地区老年人群非酒精性脂肪性肝病的临床特征及影响因素
Clinical characteristics and influencing factors of non-alcoholic fatty liver disease in the elderly at a district in Beijing
投稿时间:2022-06-01  
DOI:10.11915/j.issn.1671-5403.2022.09.141
中文关键词:  老年人  非酒精性脂肪性肝病  危险因素
英文关键词:aged  non-alcoholic fatty liver disease  risk factors This work was supported by the National Natural Science Foundation of China
基金项目:国家自然科学基金(81300252)
作者单位
尹慧君 中国人民解放军总医院第二医学中心保健八科,北京 100853 
李晓利 中国人民解放军总医院第二医学中心保健八科,北京 100853 
徐成 中国人民解放军总医院第八医学中心 重症医学科,北京 100091 
田玲 中国人民解放军总医院第八医学中心 体检中心,北京 100091 
李彬 中国人民解放军总医院第八医学中心 门诊部,北京 100091 
胡超 中国人民解放军总医院第二医学中心保健八科,北京 100853 
王耀辉 中国人民解放军总医院第二医学中心保健八科,北京 100853 
王晓晴 中国人民解放军总医院第二医学中心保健八科,北京 100853 
邓玲 中国人民解放军总医院第八医学中心 门诊部,北京 100091 
李炜 中国人民解放军总医院第八医学中心 门诊部,北京 100091 
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中文摘要:
      目的 探讨老年人群非酒精性脂肪性肝病(NAFLD)的临床特征及影响因素。方法 纳入2021年5月至2021年9月北京市海淀区≥60岁的离退休老年人782例。根据是否患有NAFLD,分为NAFLD组200例及非 NAFLD组582例。比较2组患者的基线资料。采用SPSS 25.0统计软件进行数据分析。采用多因素logistic回归分析NAFLD的影响因素。建立多指标联合预测模型,采用受试者工作特征(ROC)曲线评价其对NAFLD的临床预测价值。结果 NAFLD患病率为25.58%(200/782)。与非 NAFLD组比较,NAFLD组患者体质量指数(BMI)、糖尿病患病率、丙氨酸氨基转氨酶、天门冬氨酸氨基转移酶、甘油三酯(TG)、空腹血糖(FBG)及尿酸水平均显著升高,年龄、慢性阻塞性肺疾病患病率及高密度脂蛋白胆固醇水平均显著降低,差异均有统计学意义(均P<0.05)。多因素logistic回归分析结果显示,NAFLD与女性(OR=1.882,95%CI 1.142~3.100;P=0.013),BMI(OR=1.303,95%CI 1.219~1.393;P=0.000),FBG(OR=1.215,95%CI 1.076~1.372;P=0.002),TG(OR=1.738,95%CI 1.401~2.154;P=0.000)呈正相关,与年龄(OR= 0.979,95%CI 0.964~0.995;P=0.009)呈负相关。ROC曲线分析显示,年龄、女性、BMI、FBG及TG多指标联合对老年NAFLD有良好的预测价值,曲线下面积为0.782(95%CI 0.751~0.811)。结论 老年NAFLD患病率随年龄的增加而下降。老年NAFLD受多种因素影响,女性、肥胖、糖尿病、血脂异常尤其是TG升高,是老年人NAFLD的危险因素。
英文摘要:
      Objective To investigate the clinical characteristics and influencing factors of non-alcoholic fatty liver disease (NAFLD) in the elderly. Methods A total of 782 retired elderly people aged ≥60 years in Haidian District of Beijing were included during May and September 2021. According to whether they had NAFLD or not, they were divided into NAFLD (n=200) and non-NAFLD groups (n=582). The baseline data were compared between the 2 groups of patients. SPSS statistics 25.0 was used for data analysis. Multivariate logistic regression analysis was employed to analyze the influencing factors of NAFLD. A multi-index combined prediction model was established, and its clinical predictive value for NAFLD was evaluated by receiver operating characteristic (ROC) curve. Results The prevalence of NAFLD was 25.58% (200/782). Compared with the non-NAFLD group, the NAFLD group had significantly higher body mass index (BMI), larger proportion of diabetes, and higher levels of alanine aminotransferase, aspartate aminotransferase, triglyceride (TG), fasting blood glucose (FBG) and uric acid, and obviously younger age, lower prevalence of chronic obstructive pulmonary disease and lower high-density lipoprotein-cholesterol level (all P<0.05). Multivariate logistic regression analysis showed that NAFLD was positively correlated with female (OR=1.882,95%CI 1.142-3.100; P=0.013), BMI (OR=1.303,95%CI 1.219-1.393; P=0.000), FBG (OR=1.215,95%CI 1.076-1.372; P=0.002), TG (OR=1.738,95%CI 1.401-2.154; P=0.000), and negatively with age (OR=0.979,95%CI 0.964-0.995); P=0.009). ROC curve analysis showed that the combination of age, female, BMI, FBG and TG had a good predictive value for elderly NAFLD, with an area under the curve of 0.782 (95%CI 0.751-0.811). Conclusion The prevalence of NAFLD in the elderly is decreased with age. NAFLD in the elderly is affected by many factors. Female, obesity, diabetes and dyslipidemia, especially TG elevation, are the risk factors of NAFLD in the elderly.
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