| 赵时菊,黄高忠.类风湿关节炎心血管病变的研究进展[J].中华老年多器官疾病杂志,2022,21(8):634~637 |
| 类风湿关节炎心血管病变的研究进展 |
| Research progress in cardiovascular disease in rheumatoid arthritis |
| 投稿时间：2021-07-03 |
| DOI：10.11915/j.issn.1671-5403.2022.08.137 |
| 中文关键词: 类风湿关节炎 心血管疾病 危险因素 |
| 英文关键词:rheumatoid arthritis cardiovascular disease risk factor Corresponding author:HUANG Gao-Zhong, E-mail: huanggaozhong@126.com〖FL |
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| 中文摘要: |
| 类风湿关节炎(RA)是临床中常见的自身免疫性疾病,其病因和发病机制复杂多样,具有较高的致残率和死亡率。除了经常引起关节肿胀、压痛外,心脏受累是RA常见的关节外表现,且与RA患者的预后密切相关。与普通人群相比,RA患者发生心血管疾病(CVD)的风险明显升高,从而会进一步增加患者的死亡风险。除了传统的心血管危险因素,如高血压、高脂血症、吸烟、肥胖、糖尿病、慢性肾脏病等外,一些非传统心血管危险因素如炎症、免疫、抗风湿药物的使用等被发现在RA患者的CVD发病中起重要作用。本文对RA患者合并心脏损害的相关临床表现及危险因素等展开综述,旨在为此类患者的诊断和治疗提供一定理论帮助。 |
| 英文摘要: |
| Rheumatoid arthritis (RA) is a clinically common autoimmune disease with complex and diverse etiology and pathogenesis and with a high disability rate and mortality. Besides frequent joint swelling and tenderness,cardiac involvement is a common extra-articular manifestation of RA,which is closely related to the prognosis of RA patients. Compared with the general population, RA patients have a significantly increased risk of developing cardiovascular disease (CVD), further increasing the risk of death. In addition to conventional cardiovascular risk factors, such as hypertension,hyperlipidemia,smoking,obesity,diabetes mellitus,and chronic kidney disease, some other cardiovascular risk factors, such as inflammation, immunity, and the use of anti-rheumatic drugs, have been found to play an important role in the incidence of CVD in RA patients. This paper intends to review the clinical manifestations and risk factors of cardiac damage in RA, aiming to provide theoretical suggestions for the diagnosis and treatment of such patients. |
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