Objective To compare patient’s comfort after hemostasis with arteriotomy closure device versus manual or device compression after percutaneous coronary interventions (PCI) in the elderly patients and evaluate their impact on nursing procedures.Methods A total of 396 elderly (aged 60 years or over) patients who underwent PCI were enrolled in this study.Patients were divided into 3 groups according to whether receiving manual compression (group A,n=162),Femostop device compression (group B,n=128) or arteriotomy closure with Perclose for hemostasis (group C,n=106) after PCI.Changes of heart rate,blood pressure,degree of insomnia,dysuria,gastrointestinal symptom score and bleeding or thrombotic events were recorded before and at 6 h,24 h after PCI procedure.Results Compared with those patients receiving either manual compression or Femostop compression,patients receiving Perclose vascular closure showed less fluctuation of vital signs and better indexes of post-procedure comfort,with lower rate of post-procedure bleeding,but no differences were observed between those receiving Femostop or manual compression.No difference in thrombotic complications was found among three groups.Conclusion Hemostasis with arteriotomy closure device may improve post-procedure comfort and reduce bleeding complications in elderly patients.Different nursing protocol should be adapted for patients receiving different hemostasis to improve efficiency and quality of nursing care.