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| Clinical heterogeneity of depression after acute ischemic stroke between genders |
| Received:August 16, 2022 |
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| DOI：10.11915/j.issn.1671-5403.2023.01.009 |
| Key words:gender post-stroke depression clinical heterogeneity Hamilton Depression Scale This work was supported by the Research Projects in Medical Sciences of Hebei Province 2020 |
| Author Name | Affiliation | E-mail | | ZHANG Meng-Qi | School of Psychology and Mental Health, North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical | | DING Jia-Hao | School of Psychology and Mental Health, North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical | | HAO Ming-Xia | School of Psychology and Mental Health, North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical | | CHEN Xiao | School of Psychology and Mental Health, North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical | | LONG Li-Ting | School of Psychology and Mental Health, North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical | | TIAN Rong-Shen | Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical | | ZHANG Shuang | Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical | | YUAN Jie | Institute of Mental Health, North China University of Science and Technology, Tangshan 063000, Hebei Province, China | tsphyj@126.comclinical |
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| Abstract: |
| Objective To explore the heterogeneity of clinical symptoms between genders in patients with post-stroke depression (PSD). Methods A total of 501 patients with acute ischemic stroke in Affiliated Hospital of North China University of Science and Technology from December 2020 to February 2022 were selected as the subjects. Their general clinical data were collected, and they were evaluated with National Institutes of Health Stroke Scale (NIHSS) and the activities of Daily Living (ADL) scale within 24 hours after admission. One week after admission, the depressive mood of patients was evaluated using the 24-item Hamilton Depression Scale (HAMD-24). SPSS 26.0 was used for statistical analysis. Depending on data type, comparison between groups was performed using t test, non-parametric test or χ2 test. Results Among 501 patients with stroke, 173 (96 men and 77 women) had PSD. PSD men scored significantly higher than women [(5.44±4.25) vs (3.97±5.63) points; P<0.01] on NIHSS and significantly lower [(68.07±20.10) vs (79.35±21.69) points; P<0.01] on ADL scale. With the single symptom of HAMD-24, PSD men scored significantly lower than PSD women in depression [1.00(0.00,2.00) vs 1.00(1.00,2.00) points；P<0.05], but significantly higher in work and interest [0.00(0.00,1.00) vs 0.00(0.00,0.00) points], tardiness [0.00(0.00,1.00) vs 0.00(0.00,0.00) points], agitation [0.50(0.00,2.00) vs 0.00(0.00,1.00) points], systemic symptoms [2.00(1.00,3.00) vs 1.00(0.00,2.00) points], weight loss [1.00(0.00,2.00) vs 0.00(0.00,1.00) points] and self-awareness [0.00(0.00,1.00) vs 0.00(0.00,0.00) points] ( P<0.05 for all). Among HAMD-24 symptoms, the scores for weight loss [1.00(0.00,2.00) vs 0.00(0.00,1.00) points] and for despair [1.00(0.00,2.00) vs 0.00(0.00,2.00) points] were higher in PSD men than in PSD women (P<0.05 for both). Anxiety, somatization, and sleep disorders were the factors with higher symptom severity coefficients in PSD patients of both genders. Conclusion The clinical symptoms of PSD patients are heterogeneous between genders. Attention should be paid to the gender differences in symptoms among stroke patients of in clinical practice. |
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