Research progress in inflammatory factor-mediated HBV infection
Received:October 18, 2021  
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DOI:10.11915/j.issn.1671-5403.2022.09.153
Key words:hepatitis B virus  inflammatory factors  immune cells This work was supported by Youth Program of National Natural Science Foundation of China
Author NameAffiliation
DONG Zhuan-Li School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China 
XIAO Li-Xin Department of Epidemiology, Faculty of Preventive Medicine, Air Force Medical University, Xi′an 710032, China 
FU Ting Department of Epidemiology, Faculty of Preventive Medicine, Air Force Medical University, Xi′an 710032, China 
HE Zheng Department of Epidemiology, Faculty of Preventive Medicine, Air Force Medical University, Xi′an 710032, China 
ZHANG Wei-Lu Department of Epidemiology, Faculty of Preventive Medicine, Air Force Medical University, Xi′an 710032, China 
JI Zhao-Hua Department of Epidemiology, Faculty of Preventive Medicine, Air Force Medical University, Xi′an 710032, China 
SHAO Zhong-Jun Department of Epidemiology, Faculty of Preventive Medicine, Air Force Medical University, Xi′an 710032, China 
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Abstract:
      After hepatitis B virus (HBV) infection, the virus replicates in the human body and causes cell damage, which activates the release of inflammatory factors in immune cells and further aggravates liver damage. Inflammatory liver damage involves a variety of immune cells, and the inflammatory factors secreted by them play a vital role in cellular and humoral immune responses, antiviral activity, virus clearance, apoptosis and fibrosis formation. HBV infection leads to interaction between a wide array of immune cells and inflammatory factors, forming a complex immune response network and thus promoting the occurrence and development of hepatitis. Inflammatory factors are the main cause of inflammation and liver damage after HBV infection. This article reviews the research progress in the mechanism of inflammatory factors involved in HBV development and liver damage after HBV infection in a view to providing reference for the prevention and treatment of hepatitis B.
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