Research progress in role of abnormal metabolism of branched-chain amino acid in occurrence and development of heart failure
Received:May 19, 2021  
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DOI:10.11915/j.issn.1671-5403.2022.07.117
Key words:amino acids, branched-chain  heart failure  metabolic remodeling This work was supported by the National Natural Science Foundation of China
Author NameAffiliationE-mail
ZHAO Fei First Clinical Medical College of Lanzhou University, Lanzhou 730000, China  
NIU Xiao-Wei Department of Cardiology, First Hospital of Lanzhou University, Lanzhou 730000, China  
LIU Yong-Ming Department of Geriatric Cardiology, First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Geriatric Medicine, Lanzhou 730000, China cardtonm@263.net 
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Abstract:
      The changes of myocardial energy metabolism play an important role in the occurrence and development of heart failure. In recent years, it has been found that the increase of plasma branched-chain amino acid (BCAAs) and its metabolites is an important feature of heart failure, and forms a malignant feedback loop, which will eventually lead to the progression of heart failure. By promoting the catabolism of BCAAs, reducing the accumulation of metabolites and restoring the metabolic balance of BCAAs are expected to become a new target for the treatment of heart failure. This article reviews the association between abnormal metabolism of BCAAs and heart failure.
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