Normal people have periodic circadian rhythms of sleep-wake, and changes in circadian rhythms will cause sleep loss or disturbance. Immune dysfunction can also lead to abnormal changes in cytokine levels, leading to insomnia. Physical therapy is gradually accepted by the population because of its good adaptability. In this article, we summarize the regulating effects of various physiotherapies on the cytokines so as to provide new ideas and methods for the related treatment of insomnia disorder.