Research progress in noninvasive fractional flow reserve
Received:January 12, 2021  
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DOI:10.11915/j.issn.1671-5403.2022.04.064
Key words:hemodynamics  coronary heart disease  coronary angiography  noninvasive fractional flow reserve This work was supported by the National Natural Science Foundation of China
Author NameAffiliationE-mail
ZHOU Pei Department of Cardiology, Peking University Third Hospital, Beijing 100191, China  
CUI Ming Department of Cardiology, Peking University Third Hospital, Beijing 100191, China  
LIU Jian Department of Cardiology, Peking University People′s Hospital, Beijing 100044, China drjianliu@163.com 
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Abstract:
      Conventional coronary angiography is unable to assess coronary artery lesions precisely in patients with coronary heart disease. Fractional flow reserve (FFR) is a “golden standard” for the diagnosis of coronary ischemic lesions. However, use of pressure guide wire and vasodilator will increase the risk for invasive operation, operation time and medical costs, which limits the application of FFR in clinical practice. In recent years, several noninvasive FFR techniques are developed based on fluid dynamics, which measure FFR with coronary CT or coronary angiography images, and avoid the need for wire manipulation and hyperaemic stimulus. And these techniques also show good diagnostic efficacy in clinical trials. This article reviews these noninvasive FFR techniques.
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