Objective To explore the clinical effect of Mailuo Shutong Pills combined with rivaroxaban in the treatment of post-deep vein thrombosis syndrome of lower extremity. Methods A retrospective study was conducted of the clinical data of 60 patients with sequelae of lower extremity deep venous thrombosis treated in the Department of Vascular Surgery of Weifang People′s Hospital from June 2019 to September 2020. According to the treatment regimen, they were divided into control group (n=30) and study group (n=30). The control group received basic treatment such as rivaroxaban tablets and elastic stockings, and the study group were treated with additional Mailuo Shutong Pills. The Villalta score, fibrinogen (FIB), activated partial thromboplastin time (APTT), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were recorded. SPSS statistics 22.0 was used for data analysis. According to the data type, t-test, χ² test, or Fisher′s exact test was used for comparison between groups. Results After treatment, the study group had significantly better Villalta score (including swelling, pain and pigmentation of the affected extremity), lower inflammatory indexes (IL-6 and hs-CRP) and FIB than the control group [(6.17±2.20)vs (7.43±1.50) points, (32.35±4.68)vs(48.75±5.21)pg/ml, (13.51±3.89) vs (18.87±4.28) mg/L, (2.43±0.41)vs (2.79±0.47)g/L, P<0.05]. There were no significant differences in APTT and adverse reactions between the two groups (P>0.05). Conclusion Mailuo Shutong Pills combined with rivasaban can significantly enhance the therapeutic efficacy in PTS, improving blood coagulation and inflammatory reaction with good safety.