Objective To evaluate the patency rate of iliac vein stenting after thrombectomy in patients of deep venous thrombosis (DVT) with iliac vein compression syndrome (IVCS, also known as May-Thurner syndrome or Cockett′s syndrome). Methods Clinical data of 83 patients with acute lower limb DVT with IVCS and undergoing thrombectomy treated in Weifang People′s Hospital from January 2016 to December 2019 were collected and analyzed retrospectively. According to their treatment, they were divided into drug group (n=32) and stent group (n=51). The detumescence rate of limbs at discharge, venous patency rate and Villalta score at 6 and 12 months after operation were employed as evaluation indexes, and compared between the two groups. SPSS statistics 22.0 was used to perform the statistical analysis. Student′s t test, Chi-square test, or Fisher exact probability test was employed for intergroup comparison depending on different data types. Results The detumescence rates of thigh and calf were (29.75±11.74)% and (30.40±10.79)% in the drug group, and (64.35±12.67)% and (61.0±18.89)% in the stent group, with significant differences between the two groups (all P<0.05). The venous patency rates at 6 and 12 months after operation were 87.50% and 75.00% in the drug group and 96.07% and 92.15% in the stent group, respectively. The Villalta scores at 6 and 12 months after operation were (8.16±1.80) and (7.44±1.50) in the drug group and (6.76±2.40) and (6.17±2.11) in the stent group, with statistical differences between the two groups (P<0.05). Conclusion One-stage iliac vein stent therapy can significantly improve the patency rate of vein and improve the symptoms of lower extremities after thrombectomy in patients with DVT and IVCS of lower extremities.