Characteristics and risk factors of COPD-OSAHS overlap syndrome
Received:February 27, 2021  
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DOI:10.11915/j.issn.1671-5403.2021.11.170
Key words:pulmonary disease, chronic obstructive  obstructive sleep apnea hypopnea syndrome  overlap syndrome  risk factors This work was supported by the Key Research and Development Projects of Shaanxi Province
Author NameAffiliationE-mail
WANG Ya-Ya Department of Respiratory Diseases, Yan′an University Affiliated Hospital, Yan′an 716000, Shaanxi Province, China  
WANG Xiao-Jun Department of Respiratory Diseases, Yan′an University Affiliated Hospital, Yan′an 716000, Shaanxi Province, China  
DU Yan-Ling Department of Respiratory Diseases, Yan′an University Affiliated Hospital, Yan′an 716000, Shaanxi Province, China 964181302@qq.com 
LUAN Qiang-Qiang Department of Respiratory Diseases, Yan′an University Affiliated Hospital, Yan′an 716000, Shaanxi Province, China  
QIAN Xiao-Shun Department of Respiratory Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China  
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Abstract:
      Objective To analyze the risk factors of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea hypopnea syndrome (OSAHS) by observing the clinical characteristics of patients with COPD-OSAHS overlap syndrome (OS). Methods A total of 123 COPD patients from October 2018 to December 2019 were selected in the Department of Respiratory Diseases of Yan′an University Affiliated Hospital. They were divided into COPD group (n=64) and OS group (n=59). SPSS statistics 22.0 was used for data analysis. According to different data type, t test or χ2test was used for data comparison between two groups. Pearson correlation coefficient and multivariate logistic regression were used to analyze factors of OSAHS in the COPD patients. Results The apnea hypopnea index (AHI) of the OS group was correlated positively with neck circumference, body mass index (BMI), arterial partial pressure of carbon dioxide (PaCO2) (r=0.774,0.905,0.761, P<0.05) and negatively with forced expiratory volume in the first second to forced vital capacity(FEV1/FVC), arterial partial pressure of oxygen(PaO2) (r=-0.597, -0.856, P<0.05). Neck circumference (OR=3.453,95%CI 2.004-5.948; P=0.000), BMI (OR=3.467,95%CI 2.268-6.696; P=0.000), snoring (OR=5.925,95%CI 2.622-13.386; P=0.000), and smoking (OR=2.503,95%CI 1.076-5.822; P=0.033) were independent risk factors of COPD-OSAHS overlap syndrome. Conclusion Increased neck circumference and BMI, smoking, and snoring are risk factors of COPD-OSAHS overlap syndrome, and patients with overlap syndrome are more likely to have hypoxia and hypercapnia than COPD patients.
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