Objective To find the differentially expressed genes (DEGs) in diabetic patients combined with abdominal aortic aneurysms (AAA) through bioinformatics analysis, then clarify their functions, and explore the roles in the pathogenesis. Methods The expression profiles of GSE21321 (diabetes mellitus) and GSE7084 (AAA) were downloaded from the Gene Expression Omnibus (GEO) database. The 2 microarray datasets were integrated to obtain DEGs by screening at P<0.05 and expression changes greater than 2 times. The subcellular localization of obtained proteins was analyzed by using Genscript database and Predictprotein platform, which were further verified with fluorescence co-localization analysis. The protein interactions of hypoxia-inducible lipid droplet-associated (HILPDA)were analyzed by the search tool for the retrival of interacting genes (STRING) database. SPSS statistics 13.0 was used for data analysis. Difference of measurement data was compared with analysis of variance. Results HILPDA was screen out, with up-regulation by 11.35 times in type 2 diabetes mellitus and by 6.4 times in AAA. The results of subcellular localization predicted that HILPDA is mostly distributed in the nucleus and mitochondria. Immunofluorescence co-localization analysis confirmed that HILPDA had a higher expression in the nucleus and the mitochondria of vascular smooth muscle cells; protein-protein interaction (PPI) network analysis confirmed that HILPDA-related proteins are related to cellular response to hypoxia and lipid droplet. HILPDA protein expression was significantly higher in the AAA tissues than the peritumor arterial tissues (control group) [(47.2±5.6)% vs (71.5±4.7)%, P<0.01].Conclusion HILPDA gene might have potential guiding value in the clinical studies concerning the diagnosis and treatment of diabetes accompanied with AAA.