Countries all over the world are facing great challenges brought by the aging of the population, and our country will also enter the stage of rapid aging. Multimorbidity is quite common among the elderly, and shows profound impact on the quality of life and life expectancy. With the improvement of medical care and the continuous extension of life expectancy, there are more and more medical staffs who provide medical services to the elderly with multimorbidity. In this paper, we review the prevalence of multimorbidity, related senile syndrome, influence of disease combination on prognosis and other issues concerning health management, and hope to provide reference for health management for the elderly with multimorbidity.