Recently, the incidence of coronary heart disease has been increasing in China year by year. As a major component of the inflammatory response, white blood cells play an important role in the pathogenesis of coronary heart disease. Recent studies have shown that some leukocyte-derived inflammatory markers have crucial clinical value in predicting the diagnosis and treatment of coronary heart disease. This article reviews clinical predictive value of neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio or monocyte/lymphocyte ratio, platelet/lymphocyte ratio, and monocyte/high-density lipoprotein cholesterol ratio in the diagnosis and treatment of coronary heart disease.