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Effects of vitamin D combined with resistance training on skeletal muscle mass, activities of daily living and serological indices in elderly patients with sarcopenia |
Received:October 18, 2019 |
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DOI:10.11915/j.issn.1671-5403.2020.09.153 |
Key words:aged muscular diseases sarcopenia vitamin therapy resistance training This work was supported by the National Natural Science Foundation of Hebei Province |
Author Name | Affiliation | E-mail | SHAO Wei-Hua | Second Division of Geriatrics Department, Hebei Gerneral Hospital, Shijiazhuang 050051, China | taiyang8182@163.comeffects | GAO Li-Xia | Second Division of Geriatrics Department, Hebei Gerneral Hospital, Shijiazhuang 050051, China | taiyang8182@163.comeffects | WANG Su-Xing | Second Division of Geriatrics Department, Hebei Gerneral Hospital, Shijiazhuang 050051, China | taiyang8182@163.comeffects | LYU Cai-Xia | Second Division of Geriatrics Department, Hebei Gerneral Hospital, Shijiazhuang 050051, China | taiyang8182@163.comeffects | YAO Li-Xia | Second Division of Geriatrics Department, Hebei Gerneral Hospital, Shijiazhuang 050051, China | taiyang8182@163.comeffects | LI Shao-Bing | Second Division of Geriatrics Department, Hebei Gerneral Hospital, Shijiazhuang 050051, China | taiyang8182@163.comeffects |
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Abstract: |
Objective To observe the effects of vitamin D combined with resistance training on skeletal muscle mass, activities of daily living (ADL), and serum monocyte chemotactic factor-1 (MCP-1), interleukin-1β (IL-1β) and C-reactive protein (CRP) in the elderly patients with sarcopenia. Methods From January 2017 to May 2018,112 elderly patients with sarcopenia complicated with vitamin D deficiency were enrolled in the study, who were treated in Second Division of Geriatrics Department, Hebei Gerneral Hospital. They were randomized into control group (T1 group, n=30), resistance training group (T2 group, n=41) and resistance training plus vitamin D group (T3 group, n=41). T1 group were provided with education on sarcopenia, T2 group were given resis-tance training (twice a week, 30min each time) in addition to education on sarcopenia, and calcitriol (0.25μg, twice daily) was added for T3 group on the basis of the treatment for the T2 group. All three groups were observed for 24 weeks. The serum 25(OH)D3, MCP-1,IL-1β, CRP, grip strength, pace, ADL, and skeletal muscle mass index (SMI) of the limbs were measured before intervention and after 24 weeks of intervention for all the participants, and the changes of the above indicators were compared at the 0 week and 24 weeks. Pearson correlation analysis was made for the relationship between serum 25(OH)D3 and MCP-1, IL-1β, CRP, SMI and ADL. Results After 24 weeks of intervention, T2 and T3 groups had higher levels of serum 25(OH)D3, SMI, grip strength, pace and ADL but lower levels of MCP-1, IL-1β and CRP than those before the intervention and those of the T1 group (all P<0.05). The changes of the above indices in the T3 group were greater than those in the T2 group (all P<0.05). Pearson correlation analysis showed that serum 25(OH)D3 was positively correlated with SMI and ADL (r=0.537,0.439, all P<0.05), and negatively correlated with MCP-1, IL-1β and CRP (r=-0.544, -0.618, -0.496, all P<0.05). Conclusion Vitamin D combined with resistance training can increase muscle mass and improve daily activities in the elderly patients with sarcopenia and is better than single resistance training. The mechanism may be related to the reduction of inflammatory factors MCP-1, IL-1β and CRP. |
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