Osteoporosis is a bone disease related to aging. Its serious consequence is fracture, which is of high rates of death and disability. So, osteoporosis needs early prevention and effective and reasonable management. In late December 2019, an ongoing outbreak of coronavirus disease 2019 (COVID-19) hit Wuhan, Hubei Province, and subsequently reached other provinces. Concrete evidence shows that the elderly and the patients with comorbidities have poor prognosis, and also are the main death group. Therefore, it is of great importance to do a good job in scientific prevention, control and management of the elderly osteoporosis patients during the epidemic period. This paper summarizes the comprehensive prevention and control measures for the elderly osteoporosis patients, in order to guide the clinicians to make better management to pass the epidemic period safely.