Objective To investigate the effect of general anesthesia combined with continuous infusion of different doses of dexmedetomidine on elderly patients with hip fracture. Methods From January to December 2018,9 elderly patients with hip fracture admitted in our hospital were enrolled in this study. They were randomly divided into low-dose dexmedetomidine group (n=45) and high-dose group (n=44). Continuous infusion of dexmedetomidine as adjuvant anesthesia was given at 0.5μg/(kg·h) for the patients in the low-dose group, and at 1.0μg/(kg·h) for those in the high-dose group. The extubation and recovery time, mean arterial pressure (MAP) and heart rate (HR) at pre-anesthesia (T0), post-anesthesia induction (T1), after infusion of dexmedetomidine for 15min (T2) and end of operation (T3), as well as the levels of pre- and post-operative stress response indicators were compared between the 2 groups. SPSS statistics 18.0 was used for data analysis. Results The recovery time [(13.42±0.69) vs (16.91±1.08)min] and extubation time [(20.17±2.46) vs (27.63±3.02)min] were significantly shorter in the low-dose group than the high-dose group (P<0.05). Compared with the levels at T0, MAP and HR at T1, T2 and T3 time points were obviously decreased in both groups (P<0.05). There was no differences in the 2 indicators at the above time points between the 2 groups (P>0.05). The levels of cortisol [(189.24±23.76) vs (153.48±20.57)μg/L; (182.63±24.81) vs (152.88±21.72)μg/L] and aldosterone [(49.21±8.62) vs (33.76±5.80)pg/L; (47.29±4.02) vs (34.07±3.97)pg/L] at 2h after operation were notably higher than those before operation in the 2 groups (P<0.05). But no differences were found in the levels of adrenaline, cortisol, noradrenaline and aldosterone between the 2 groups before and 2h after operation (P>0.05). Conclusion Continuous infusion of high and low dose dexmedetomidine combined with general anesthesia can stabilize hemodynamic indicators in the elderly patients with hip fracture, but low dose can shorten the extubation time and recovery time.