Obstructive sleep apnea syndrome(OSAS) is a common sleep disorder and a risk factor for osteoporosis. Bone mineral density tends to decrease in OSAS patients, but studies by different scholars have shown that bone density increases or remains unchanged. Bone turnover markers, including bone resorption markers and bone formation markers, reflect quickly changes in bone metabolism as compared with bone density. Long-term chronic intermittent hypoxia in OSAS patients induces alterations in the genes related to bone metabolism, affecting bone metabolism through signaling pathways such as changes in nuclear factor-κB. However, this has not been confirmed clinically and the related mechanism remains unknown.