Objective To compare the difference of volume of epicardial adipose tissue (EAT) between the patients with sick sinus syndrome(SSS) and health people, and explore the correlation of EAT with the presence of SSS. Methods A total of 65 SSS patients admitted in our medical center from January 2017 to January 2018 were subjected in this study, and another 65 health individuals with matched age, sex, and body mass index (BMI) during same period served as controls. Their demographic data and comorbid conditions were collected. Coronary CT scan was performed for total EAT (EAT-total) volume, atrial EAT (EAT-atrial) volume, right atrial EAT (EAT-RA) volume, left atrial EAT (EAT-LA) volume and ventricular EAT (EAT-ventricular) volume. The obtained parameters were compared between the 2 groups, and the correlation between EAT and presence of SSS were evaluated. SPSS statistics was used to perform the statistical analysis. Results Besides EAT-ventricular volume, the other EAT volumes were significantly greater in the patients with SSS than the health controls [EAT-atrial:(68.7±29.1) vs (55.3±19.6)cm³, P<0.05; EAT-LA:(39.5±19.3) vs (31.9±11.9)cm³, P<0.05; EAT-RA:(29.2±11.5) vs (23.4±8.7)cm³, P<0.05; EAT-total:(150.5±61.2) vs (130.5±42.1)cm³,P<0.05]. Multivariate linear regression analysis revealed that EAT-atrial volume and EAT-RA volume were independently associated with the presence of SSS after adjustment for possible confounding factors. Conclusion Accumulation of epicardial adipose tissue is seen in the SSS patients. The accumulation may play a role in the occurrence and development of the disease.