Early prediction of serum level of neutrophil gelatinase-associated lipid carrier protein for contrast-induced nephropathy
Received:December 11, 2018  
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Key words:neutrophil  lipocalin  contrast media
Author NameAffiliationE-mail
LI Xiu-Zhen Department of Cardiology,  
TAN Xiao Emergency Center,  
GAO Yi-Bing Emergency Center,  
GAO Ying Emergency Center,  
ZHU Rong Emergency Center,  
LIU Yang Department of Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China  
WANG Di-Bin Department of Cardiology, power870310@126.com 
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      Objective To observe the change of serum neutrophil gelatinase-associated lipocalin (NGAL) level before and after coronary angiography (CAG) and percutaneous coronary intervention (PCI) in patients with coronary heart disease, and to investigate its predictive value of NGAL for contrast-induced nephropathy (CIN). Methods A total of 136 patients who underwent CAG and PCI in the Department of Cardiology and Emergency Center of our hospital from April 2017 to April 2018 were recruited, and their clinical data were collected and retrospectively analyzed. According to the occurrence of CIN, they were assigned into CIN group (n=10) and non-CIN group (n=126). The serum creatinine (SCr), blood urea nitrogen (BUN) and NGAL levels before and at 24 h and 48 h after operation were compared between 2 groups, and the predictive value of NGAL for CIN was analyzed by receiver operating characteristic (ROC) curve. The data were analyzed by SPSS statistics 22.0. Student′s t test, ANOVA or Chi-square test was used for comparison between 2 groups. Results The CIN group had significantly increased levels of 48 h SCr, 24 h BUN, 48 h BUN and 24 h NGAL than those indices before operation (P<0.05). Compared with the non-CIN group, the CIN group had obviously higher 48 h SCr [(174.95±15.77) vs (97.69±9.33)μmol/L], 24 h BUN [(7.75±1.75) vs (5.07±1.35)mmol/L], 48 h BUN [(8.92±2.03) vs (5.17±1.31)mmol/L], and 24 h NGAL [(457.68±220.69) vs (185.82±51.41)ng/ml](all P<0.05). ROC curve showed that the cut-off value of 24 h NGAL for predicting CIN was 40.325 ng/ml, and the area under the curve was 0.852, with a sensitivity of 70% and a specificity of 100%. Conclusion The serum level of NGAL is significantly increased in coronary heart disease patients at 24 h after PCI and CAG, and the index shows early predictive value for CIN.