Efficacy of Chaihu Shugan powder combined with rabeprazole in the treatment of peptic ulcer in the elderly
Received:May 21, 2018  Revised:September 07, 2018
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DOI:10.11915/j.issn.1671-5403.2018.12.212
Key words:aged  peptic ulcer  inflammatory factor  growth factor  rabeprazole
Author NameAffiliationE-mail
PENG Yan Department of Gastroenterology, People′s Hospital of Dianjiang County, Chongqing 408300, China  
LIU Pei Department of Gastroenterology, People′s Hospital of Dianjiang County, Chongqing 408300, China 261691601@qq.com 
CHEN Qi Department of Gastroenterology, People′s Hospital of Dianjiang County, Chongqing 408300, China  
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Abstract:
      Objective To analyze clinical efficacy of Chaihu Shugan powder combined with rabeprazole in the treatment of peptic ulcer in the elderly. Methods A total of 126 senile patients with peptic ulcer were selected for the study, who were treated in the Department of Gastroenterology, People′s Hospital of Dianjiang County. The patients were randomized into the control group and the observation group with 63 in each. The two groups were treated with rabeprazole-based triple therapy, with Chaihu Shugan Powder added into the therapeutic regimen for the observation group. After 4 weeks of continuous treatment, comparisons were made between the two groups in the aspects of efficacy, levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α) before and after the treatment, and adverse reactions. Data was processed using SPSS statistics 13.0. Depending on data type, Student′s t test or χ2 test was performed for comparison between groups. Results Compared with control group, the observation group had significantly lower level of serum IL-6 [(3.45±1.08) vs (4.28±1.76)μg/L] and TNF-α [(9.35±2.79) vs (10.64±3.05)μg/L] but significantly higher level of EGF [ (0.84±0.26) vs (0.72±0.22)ng/ml] and TGF-α [(7.55±1.93) vs (6.01±1.86)μg/ml], the differences being statistically significant (P<0.05). The total effective rate was 87.30% in the control group as against 98.41% in the observation group with significant difference (P<0.05). The clearance rate of Helicobacter pylori in the observation group was significantly higher than that in the control group (92.06% vs 71.43%; P<0.05). The incidence of adverse reactions was 15.87% in the control group and 14.28% in the observation group with no significant difference (P>0.05). Conclusion Chaihu Shugan powder combined with rabeprazole has definite efficacy in the treatment of peptic ulcer in the elderly, alleviating inflammation, increasing the level of growth factor, and promoting ulcer healing.
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