Objective To analyze the related factors impairing activities of daily living (ADL) in the hospitalized elderly patients in order to provide rational medical care services for them. Methods Comprehensive geriatric assessment was carried out on 100 elderly patients hospitalized in our geriatric department from October 2016 to March 2017. The relationship of ADL with chronic disease, home care, and results of comprehensive geriatric assessment was analyzed. SPSS statistics 22.0 was used to analyze the data. The measurement data were expressed as mean±standard deviation. Spearman correlation analysis was employed for single continuous variable, Chi-square test for binary variables, and logistic regression analysis for multiple factors. Results Among the 100 participants, 37 peoples had activity impaired, with a score of (5.22±1.36). Single factor correlation analysis showed that age, grip strength, fall history, and results of short-form Mini-Nutritional Assessment (MNA-SF) and Mini-Mental State Examination (MMSE) were independent factors for ADL (P<0.05). While multiple factors correlation analysis indicated that age, grip strength, and fall history were correlated with ADL (P<0.05). The severity of impaired ADL were correlated with gender and MMSE (P<0.05), but whether there was relationship with other items remained unclear. Conclusion For ADL impaired elderly people, they can prevent function decline by exercising grip strength, being cautious about fall, strengthening nutrition, and preventing dementia.