Due to untypical manifestations, missed diagnosis and misdiagnosis of Castleman’s disease are very common in clinical practice. It is essential to grasp its clinicopathological characteristics to reduce missed diagnosis and misdiagnosis. In this paper, we reported one patient with clinical manifestations of fever, kidney injury and lymphadenectasis. After admission, the patient was finally diagnosed as Castleman’s disease with pathological finding, combined with clinical manifestations and laboratory results. We expect that this report will promote the understanding and diagnosis of the disease for clinicians.