Objective To investigate the correlation between low-density lipoprotein cholesterol (LDL-C) level and HAS-BLED score in elderly patients with comorbidities and non-valvular atrial fibrillation (AF), in order to provide new thoughts for clinical decision-making in lipid-lowering and anticoagulation therapy. Methods A retrospective analysis was carried out on 139 elderly patients with comorbidities and non-valvular AF, and CHA2DS2-VASc score ≥2 hospitalized in our department from January 2013 to December 2016. They were 85 males and 54 females, at an age of(78.9±8.2) years, and were divided into low-bleeding-risk group (HAS-BLED <3, n=74) and high-bleeding-risk group (HAS-BLED ≥3, n=65). Clinical features of comorbidities and poly-pharmacy and laboratory biochemical indices were compared between the 2 groups. The correlation of LDL-C level and HAS-BLED score was analyzed. Clinical data were analyzed by SPSS statistics 22.0. The differences were compared with t test or Chi-square test respectively. Binary logistic regression analysis was adopted for the correlation of LDL-C level and HAS-BLED score. Results The high-bleeding-risk group had significantly higher CHA2DS2-VASc score and LDL-C level, older age, and larger proportions of hypertension and ischemic cerebral stroke, but smaller proportion of heart failure when compared with the low-bleeding-risk group (P<0.05). After adjustment of many confounding factors for lipids level and HAS-BLED score, LDL-C level (OR=2.066,5%CI 1.089-3.921,P=0.026) and age (OR=1.072,5%CI 1.011-1.137, P=0.02) were positively correlated with HAS-BLED score. Conclusion For elder patients with comorbidities, and CHA2DS2-VASc score ≥2 non-valvular AF, higher LDL-C level and older age may increase the risk for bleeding events. So, LDL-C level should be closely monitored for such patients.