With the development of contemporary cardiology and the extensive application of contrast media, the incidence of contrast-induced acute kidney injury (CI-AKI) is increased gradually. In clinical practice, early diagnosis and intervention may reverse the disease. Serum creatinine is utilized as the diagnostic standard, but it can be influenced by many factors, and cannot well reflect the renal injury. Researchers have found some new biomarkers which can accurately reflect kidney damage in the early stage of CI-AKI. In this article, we reviewed the progress of these main biomarkers. It can be expected that they will play important roles in the early diagnosis of the disease, and provide effective evidences for diagnosis and treatment.