Objective To evaluate the impact of different time interval of staged percutaneous coronary intervention(PCI) on renal function of elderly patients. Methods Totally 417 elderly of multivessel disease (MVD) patients with unstable angina(UA)or non-ST segment elevation myocardial infarction(NSTEMI), who received staged PCI from January 2014 to June 2016,were analyzed retrospectively. They were divided into the short interval group (n=172) and the long interval group (n=245) by the time interval of staged PCI. The clinical data were recorded including age, gender, body mass, serum creatinine (SCr) before and after PCI. Body mass index(BMI), the risk score for prediction of contrast-induced acute kidney injury(CI-AKI),and the estimated glomerular filtration rate(eGFR) were obtained. Renal function in patients of the two groups was statistically analyzed. SPSS statistics 15.0 was used to perform the statistical analysis. Measurement data and enumeration data were compared with t test or Chi-square test respectively. Results The clinical data including age, gender, BMI, SCr and the risk score for prediction of CI-AKI were not significantly different between the two groups before PCI(P>0.05). There was no statistical difference of renal function in the two groups before and after PCI(P>0.05), neither in the incidence of CI-AKI between two groups (2.90% in the short interval group versus 2.45% in the long interval group, P=0.77). No serious adverse events, such as emergency dialysis, new-onset acute myocardial infarction, acute stroke, emergency revascularization, or death, was reported during hospitalization. Conclusion The difference in time intervals of staged PCI has no obvious impact on renal function of elderly MVD patients with UA/NSTEMI. It is safe and feasible for patients with low or moderate risk of CI-AKI to undergo staged PCI after a short time interval.