Chronic inflammation is a major risk factor for aging and senescence-related diseases, and insulin resistance also plays a role in the process of aging. Chronic inflammation impairs lipid accumulation, adipose tissue function, mitochondrial function, and causes endoplasmic reticulum (ER) stress, and all of these lead to insulin resistance. However, evidence shows that abnormal distribution of adipose tissue also causes chronic inflammation, while chronic inflammation further aggravates insulin resistance. Their interactions accelerates the aging process. However, some studies indicate that insulin resistance itself amplifies chronic inflammation.The activity of the insulin-dependent Akt signaling pathway is of importance due to its decrease in insulin-sensitive organs, like the liver and muscle, and its increase in non-metabolic organs, such as the kidneys and aorta,which may underlie insulin resistance and hyperinsulinemia.