Value of 99mTc-MIBI gated myocardial perfusion imaging before and after percutaneous coronary intervention
Received:June 07, 2016  Revised:July 04, 2016
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Key words:gated myocardial perfusion imaging  percutaneous coronary intervention  efficiency evaluation
Author NameAffiliationE-mail
ZHANG Guo-Jian1, WANG Xue-Mei1, WEI Li-Hong2, NING Rong-Xia3* 1Department of Nuclear Medicine, 3Department of High Pressure Oxygen, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
2Department of Pharmacy, Inner Mongolia International Hospital of Mongolian Medicine, Hohhot 010065, China 
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      Objective To evaluate the clinical values of 99mTc-methoxyisobutylisonitrile (MIBI) gated myocardial perfusion imaging (MPI) in rest and stress states for coronary artery disease (CAD) patients before and after percutaneous coronary intervention (PCI). Methods Thirty CAD patients admitted in our affiliated hospital of Inner Mongolia Medical University from September 2014 to December 2015 were enrolled in the study. They all underwent PCI and 99mTc-MIBI stress/rest gated MPI in 2 weeks before and 3 months after PCI. The abnormal segments and stress/rest scores of MPI before and after PCI or stent implantation, left ventricular ejection fraction (LVEF), end-diastolic volume (EDV), end-systolic volume (ESV) and segments of wall motion abnormalities before and after PCI were evaluated by ECTOOLBOX. Results There were 320 segments corresponding to 44 vessels with stenosis >75%. Significant differences were observed in the number of abnormal segments in the myocardial reversible defect (RD) patients before and in 3 months after operation (χ2=231.867, P<0.001), but not in the number among the myocardial fixed defect (FD) patients before and after the treatment (χ2=3.398, P>0.05). There were obvious differences in the summed stress score (SSS) and summed rest score (SRS) in the RD patients before and in 3 months after treatment (t=2.457, 2.115, P<0.05), so were in the SSS in the FD patients (t=2.042, P<0.05), but not in the SRS (t=0.258, P>0.05). The values of LVEF, EDV and ESV were all elevated after surgery, though without statistical differences (t=0.075, 0.032, 0.022, P>0.05). The number of segments of wall motion abnormalities had no significant difference before and after PCI (χ2=3.570, P>0.05). Conclusion 99mTc-MIBI stress/rest gated MPI is of guiding significance in therapeutic regimen, case selection, risk stratification before PCI and in the evaluation of the efficiency after PCI.