Sepsis is a life-threatening condition caused by dysregulated host response to infection. The early organ dysfunction may be not easy to find. Though biotechnology and medical surveillance means have developed rapidly, early diagnosis of sepsis is still very difficult, and its mortality is very high. So, early diagnosis is of great significance for sepsis. In this article, we reviewed and summarized the current advances in the early diagnostic markers for sepsis, and hoped to have some implications for its clinical and scientific researches.