Objective To investigate the therapeutic effect of transurethral plasma kinetic enucleation of the prostate (TUPK-EP)for huge benign prostatic hyperplasia (BPH). Methods A total of 65 patients with huge BPH admitted in our hospital from January 2013 to December 2015 were recruited in this study. They were divided into the TUPK-EP group (n=33) and transurethral plasma kinetic resection of the prostate(TUPK-RP) group (n=32). Efficacy, maximum urinary flow rate (Qmax), and residual urine volume (PVR) were analyzed and compared between the 2 groups. Results Compared with the TUPK-RP group, the patients of the TUPK-EP group had significantly shorter operation time, smaller amount of lavage fluid, reduced intra-operative bleeding volume, decreased hemoglobin (Hb) levels, but larger removal size (P<0.05).In 3 months after operation, the Qmaxvalue was higher, but the PVR was lower in the TUKP-EP group than in the TUKP-RP group (P<0.05). Conclusion In the treatment of huge BPH, TUKP-EP is superior to TUKP-RP in radical removal of the gland, shorter operation time and reduced blood loss.It is worthy of promotion in clinical practice.