Objective To modify inappropriate prescription by means of medication reconciliation in the elderly inpatients. Methods Pharmacists were asked to participate in daily rounds and help geriatrician to perform medication reconciliation in the geriatric ward in our hospital from June 2012 to October 2013, and a total of 208 inpatients aged over 65 (76.0±6.8) years were enrolled. The outcomes were observed and analyzed. Results The participants had multiple chronic conditions (MCC) of 8.0±3.8, and drug types of 4.8±3.5. There were 48.1% of them having polypharmacy. Women took more types of drug than men ［（5.3±3.7） vs （4.3±3.2）, P=0.035］. The most commonly used drugs were for cardio-cerebrovascular diseases (78.8%), followed by those for digestive system diseases (51.4%), prostate diseases (30.8%), osteoporosis (24.5%) and diabetes (24.5%). Irrational drug use was found in 63.9% subjects at admission, and the rate of adverse drug reaction was 13.9%. The most common drugs with potential risk for adverse reaction were those for central nervous system and cardiovascular system. Those older than 85 years had significantly higher percentage of polypharmacy (χ2=4.78, P=0.03) and inappropriate prescription (χ2=3.91, P=0.048). Totally 133 patients (63.9%) accepted medication reconciliation with a changed drug list. Conclusion Elderly inpatients had more multi-comorbidities as well as more frequent polypharmacy. Medication reconciliation is an effective method to find inappropriate prescription and make timely intervention.