Predictive value of red blood cell distribution width in progression of non-culprit plaque in patients with acute coronary syndrome
Received:February 23, 2016  Revised:April 21, 2016
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DOI:10.11915/j.issn.1671-5403.2016.05.086
Key words:red blood cell distribution width  acute coronary syndrome  non-culprit plaque
Author NameAffiliationE-mail
HAN Tian-Wen, ZHOU Shan-Shan, ZHOU Ying, MU Yang, CHEN Yun-Dai* Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China cyundai@126.com 
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Abstract:
      Objective To assess the value of red blood cell distribution width (RDW) in predicting the progression of non-culprit plaque in the patients with acute coronary syndrome (ACS). Methods A total of 421 ACS patients who underwent percutaneous coronary intervention (PCI) in our center of cardiac intervention from 1st August 2008 to 1st August 2013 were enrolled in this study. According to the results of plaque progression by 3D-quantitative coronary angiography (3D-QCA), the patients were divided into the progression group (n=109) and the non-progression group (n=312). The related clinical data and traditional risk factors of coronary disease were compared to evaluate the relationship between RDW and the progression of non-culprit plaque by logistic regression analysis. Results Compared with the non-progression group, the progression group had obvious higher values of RDW [(13.08±0.73)% vs (12.89±0.71)%, P=0.020)]. The analysis on the plaque progression in the quartile subgroups of RDW indicated that there were more patients with progression of non-culprit lesion in the higher quartile subgroup of RDW (P<0.05). Multivariate regression analysis revealed that RDW (adjusted OR=1.385, P=0.045) and diabetes (adjusted OR=1.809, P=0.026) were 2 independent risk factors for predicting the progression of non-culprit lesion in the patients with ACS. Conclusion RDW can predict the progression of non-culprit plaque in the ACS patients to some extent.
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